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Research Activity

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Pennine MSK Partnership Ltd works with the research arm of the NHS, the National Institute for Health Research, to promote clinical research and offer our patients the opportunity to take part in ethically approved research studies.

Click to see how we support NHS Research and how you can help and get involved.


Audit and National Registers

National Early Inflammatory Arthritis Audit

The National Early Inflammatory Arthritis Audit has been commissioned to help understand and improve the quality of care for people with arthritis. The project collects information on people referred to rheumatology units with a possible arthritis. This is an opportunity to contribute to a national study which will shape the scope of inflammatory arthritis treatment in the future, and help improve referrals and treatment for the next generation. Pennine MSK will provide information about your care over the first 12 months after you have been diagnosed. In addition you are asked how arthritis is affecting your life. This is in the form of an online   questionnaire (paper format available if preferred) three times over 12 months – when you are diagnosed, after 3 months and one year after your diagnosis.

The first and second reports have been published and are available to view at: 1st audit report and 2nd audit report

British Society for Rheumatology Biologics Register (BSRBR)

The BSRBR-RA (British Society for Rheumatology Biologics Register –Rheumatoid Arthritis) is run by the Arthritis Research UK Epidemiology Unit at the University of Manchester. It tracks the progress of patients with severe Rheumatoid Arthritis (RA), who are receiving biologic agents Benepali, Cimzia, Enbrel, Erelzi, Flixabi, Humira, Inflectra, Kevzara, Olumiant, Remsima, Remicade, Rixathon, RoActemra and Xeljanz, and monitoring the safety and effectiveness of these treatments over a long-term period. For more information refer to the BSRBR website:

Fracture Liaison Service

Pennine MSK runs a fracture liaison service for patients over 50 years old that have broken a bone following a simple fall.  This can mean that they are at increased risk of Osteoporosis or a second fracture. The service will then aim to investigate, arrange appropriate tests and any treatment the patient needs. There is a national Fracture Liaison Service Database which Pennine MSK recruits to.   The aim of the database is to improve the care of patients who are at risk of a fragility fracture or osteoporosis. Information gathered about fracture care, treatment and referrals enables us to measure the quality of that care, identify differences, to see if guidelines are being followed and provide recommendations.  You can find further information here

Methotrexate use Improvement in Rheumatoid Arthritis – The MIRA Trial
The MIRA trail is looking at people with Rheumatoid Arthritis who have been taking Methotrexate for over 2 years. The purpose of MIRA is to explore whether a review of how well patients are coping with Methotrexate can improve RA control. Understanding the reasons for poor RA control has the potential to improve the health and well-being of individual patients, avoid unnecessary tests and hospital appointments and save money in healthcare.  Those who agree to take part in the MIRA study will be required to attend up to 2 face to face clinic visits and up to 2 telephone conversations with the research team.

For further information about research or audit contact: